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Compare $IONS vs $SYRE | Chartloom

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$IONS vs $SYRE

Ionis Pharmaceuticals Inc · Spyre Therapeutics Inc

IONS

Ionis Pharmaceuticals Inc

SYRE

Spyre Therapeutics Inc

Compare $IONS vs $SYRE

Comparing Ionis Pharmaceuticals Inc and Spyre Therapeutics Inc

IONSIonis Pharmaceuticals Inc

SYRESpyre Therapeutics Inc

IONSIonis Pharmaceuticals Inc

Market cap

$7.52B

P/E (TTM)

—

Forward P/E (NTM)

—

Forward P/S (NTM)

7.89x

Rev growth (TTM)

-7.4%

YTD performance

-43.2%

52W performance

-35.3%

FCF yield

-7.5%

SYRESpyre Therapeutics Inc

Market cap

$7.44B

P/E (TTM)

—

Forward P/E (NTM)

—

Forward P/S (NTM)

—

Rev growth (TTM)

—

YTD performance

180.2%

52W performance

384.7%

FCF yield

-2.8%

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Relative performance

Each ticker starts at 100. 110 means +10% from the start of this window — not a $110 share price.

IONS

SYRE

Detailed metrics comparison

IONS

Ionis Pharmaceuticals Inc

SYRE

Spyre Therapeutics Inc

Market Cap

IONS$7.52B

SYRE$7.44B

Enterprise Value

IONS$9.09B

SYRE$7.28B

Price

IONS$45.28

SYRE$85.69

P/E Ratio

IONSN/A

SYREN/A

P/S Ratio

IONS8.61x

SYRE6,680.42x

EV/Sales

IONS10.40x

SYRE0.00x

EV/EBITDA

IONS262.66x

SYRE0.00x

P/B Ratio

IONS16.45x

SYRE7.46x

P/FCF Ratio

IONSN/A

SYREN/A

EV/FCF

IONS-16.20x

SYRE-34.84x

PEG Ratio

IONSN/A

SYREN/A

Forward P/E (NTM)

IONSN/A

SYREN/A

Forward P/S (NTM)

IONS7.89x

SYREN/A

Revenue (TTM)

IONS$874M

SYRE$0

Revenue Growth (YoY)

IONS-7.4%

SYREN/A

Forward Rev Growth

IONS51.4%

SYRE231.1%

Gross Margin (TTM)

IONS98.2%

SYRE0.0%

Operating Margin (TTM)

IONS0.0%

SYRE0.0%

EBITDA Margin (TTM)

IONS-66.3%

SYRE0.0%

Net Margin (TTM)

IONS-64.7%

SYRE0.0%

FCF Margin (TTM)

IONS-64.2%

SYREN/A

Net Income (TTM)

IONS$-565M

SYRE$-179M

FCF (TTM)

IONS$-561M

SYRE$-209M

EPS (TTM)

IONS-$3.42

SYRE-$2.11

ROE (TTM)

IONS-11092.0%

SYRE-2432.0%

ROA (TTM)

IONS-1739.0%

SYRE-2223.0%

ROIC (TTM)

IONS-2175.0%

SYRE-2432.0%

Cash

IONS$350M

SYRE$162M

Debt

IONS$1.91B

SYRE$0

Net Cash/Debt

IONS$-1.56B

SYRE$162M

Current Ratio (TTM)

IONS7.89x

SYRE18.53x

Quick Ratio (TTM)

IONS7.73x

SYRE18.09x

Debt/Equity (TTM)

IONS4.35x

SYRE0.00x

Debt/Assets (TTM)

IONS0.0%

SYRE0.0%

Interest Coverage (TTM)

IONSN/A

SYREN/A

Net Debt/EBITDA (TTM)

IONS0.00x

SYRE0.00x

Beta

IONS0.38

SYRE3.19

52W Performance

IONS-35.3%

SYRE384.7%

YTD Performance

IONS-43.2%

SYRE180.2%

% from 52W High

IONS-47.8%

SYRE-22.2%

% from 52W Low

IONS6.2%

SYRE385.5%

Asset Turnover (TTM)

IONS0.27x

SYRE0.01x

FCF Yield (TTM)

IONS-7.5%

SYRE-2.8%

Earnings Yield (TTM)

IONS-7.5%

SYRE-2.4%

Dividend Yield (TTM)

IONSN/A

SYREN/A

Rule of 40

IONS-71.6

SYRE0.0

EV/GP/RG

IONS0.95

SYREN/A

Ticker research

View IONS research View SYRE research

Metric	IONS Ionis Pharmaceuticals Inc	SYRE Spyre Therapeutics Inc
Market & Valuation
Market Cap	$7.52B	$7.44B
Enterprise Value	$9.09B	$7.28B
Price	$45.28	$85.69
P/E Ratio	N/A	N/A
P/S Ratio	8.61x	6,680.42x
EV/Sales	10.40x	0.00x
EV/EBITDA	262.66x	0.00x
P/B Ratio	16.45x	7.46x
P/FCF Ratio	N/A	N/A
EV/FCF	-16.20x	-34.84x
PEG Ratio	N/A	N/A
Forward P/E (NTM)	N/A	N/A
Forward P/S (NTM)	7.89x	N/A
Revenue & Growth
Revenue (TTM)	$874M	$0
Revenue Growth (YoY)	-7.4%	N/A
Forward Rev Growth	51.4%	231.1%
Profitability
Gross Margin (TTM)	98.2%	0.0%
Operating Margin (TTM)	0.0%	0.0%
EBITDA Margin (TTM)	-66.3%	0.0%
Net Margin (TTM)	-64.7%	0.0%
FCF Margin (TTM)	-64.2%	N/A
Net Income (TTM)	$-565M	$-179M
FCF (TTM)	$-561M	$-209M
EPS (TTM)	-$3.42	-$2.11
ROE (TTM)	-11092.0%	-2432.0%
ROA (TTM)	-1739.0%	-2223.0%
ROIC (TTM)	-2175.0%	-2432.0%
Financial Health
Cash	$350M	$162M
Debt	$1.91B	$0
Net Cash/Debt	$-1.56B	$162M
Current Ratio (TTM)	7.89x	18.53x
Quick Ratio (TTM)	7.73x	18.09x
Debt/Equity (TTM)	4.35x	0.00x
Debt/Assets (TTM)	0.0%	0.0%
Interest Coverage (TTM)	N/A	N/A
Net Debt/EBITDA (TTM)	0.00x	0.00x
Performance
Beta	0.38	3.19
52W Performance	-35.3%	384.7%
YTD Performance	-43.2%	180.2%
% from 52W High	-47.8%	-22.2%
% from 52W Low	6.2%	385.5%
Efficiency & Yields
Asset Turnover (TTM)	0.27x	0.01x
FCF Yield (TTM)	-7.5%	-2.8%
Earnings Yield (TTM)	-7.5%	-2.4%
Dividend Yield (TTM)	N/A	N/A
Other
Rule of 40	-71.6	0.0
EV/GP/RG	0.95	N/A
Ticker research	View IONS research	View SYRE research

Valuation

P/S Ratio

IONS

8.61x

SYRE

6,680.42x

EV/FCF

SYRE

-34.84x

IONS

-16.20x

Growth & revenue

Revenue Growth TTM

IONS

-7.4%

Forward Revenue Growth

SYRE

231.1%

IONS

51.4%

Profitability & performance

Gross Margin

IONS

98.2%

SYRE

0.0%

ROE

SYRE

-2432.0%

IONS

-11092.0%

FCF Yield %

SYRE

-2.8%

IONS

-7.5%

52-Week Performance

SYRE

384.7%

IONS

-35.3%

Detailed metrics comparison

IONS

Ionis Pharmaceuticals Inc

SYRE

Spyre Therapeutics Inc

Market Cap

IONS$7.52B

SYRE$7.44B

Enterprise Value

IONS$9.09B

SYRE$7.28B

Price

IONS$45.28

SYRE$85.69

P/E Ratio

IONSN/A

SYREN/A

P/S Ratio

IONS8.61x

SYRE6,680.42x

EV/Sales

IONS10.40x

SYRE0.00x

EV/EBITDA

IONS262.66x

SYRE0.00x

P/B Ratio

IONS16.45x

SYRE7.46x

P/FCF Ratio

IONSN/A

SYREN/A

EV/FCF

IONS-16.20x

SYRE-34.84x

PEG Ratio

IONSN/A

SYREN/A

Forward P/E (NTM)

IONSN/A

SYREN/A

Forward P/S (NTM)

IONS7.89x

SYREN/A

Revenue (TTM)

IONS$874M

SYRE$0

Revenue Growth (YoY)

IONS-7.4%

SYREN/A

Forward Rev Growth

IONS51.4%

SYRE231.1%

Gross Margin (TTM)

IONS98.2%

SYRE0.0%

Operating Margin (TTM)

IONS0.0%

SYRE0.0%

EBITDA Margin (TTM)

IONS-66.3%

SYRE0.0%

Net Margin (TTM)

IONS-64.7%

SYRE0.0%

FCF Margin (TTM)

IONS-64.2%

SYREN/A

Net Income (TTM)

IONS$-565M

SYRE$-179M

FCF (TTM)

IONS$-561M

SYRE$-209M

EPS (TTM)

IONS-$3.42

SYRE-$2.11

ROE (TTM)

IONS-11092.0%

SYRE-2432.0%

ROA (TTM)

IONS-1739.0%

SYRE-2223.0%

ROIC (TTM)

IONS-2175.0%

SYRE-2432.0%

Cash

IONS$350M

SYRE$162M

Debt

IONS$1.91B

SYRE$0

Net Cash/Debt

IONS$-1.56B

SYRE$162M

Current Ratio (TTM)

IONS7.89x

SYRE18.53x

Quick Ratio (TTM)

IONS7.73x

SYRE18.09x

Debt/Equity (TTM)

IONS4.35x

SYRE0.00x

Debt/Assets (TTM)

IONS0.0%

SYRE0.0%

Interest Coverage (TTM)

IONSN/A

SYREN/A

Net Debt/EBITDA (TTM)

IONS0.00x

SYRE0.00x

Beta

IONS0.38

SYRE3.19

52W Performance

IONS-35.3%

SYRE384.7%

YTD Performance

IONS-43.2%

SYRE180.2%

% from 52W High

IONS-47.8%

SYRE-22.2%

% from 52W Low

IONS6.2%

SYRE385.5%

Asset Turnover (TTM)

IONS0.27x

SYRE0.01x

FCF Yield (TTM)

IONS-7.5%

SYRE-2.8%

Earnings Yield (TTM)

IONS-7.5%

SYRE-2.4%

Dividend Yield (TTM)

IONSN/A

SYREN/A

Rule of 40

IONS-71.6

SYRE0.0

EV/GP/RG

IONS0.95

SYREN/A

Ticker research

View IONS research View SYRE research

Metric	IONS Ionis Pharmaceuticals Inc	SYRE Spyre Therapeutics Inc
Market & Valuation
Market Cap	$7.52B	$7.44B
Enterprise Value	$9.09B	$7.28B
Price	$45.28	$85.69
P/E Ratio	N/A	N/A
P/S Ratio	8.61x	6,680.42x
EV/Sales	10.40x	0.00x
EV/EBITDA	262.66x	0.00x
P/B Ratio	16.45x	7.46x
P/FCF Ratio	N/A	N/A
EV/FCF	-16.20x	-34.84x
PEG Ratio	N/A	N/A
Forward P/E (NTM)	N/A	N/A
Forward P/S (NTM)	7.89x	N/A
Revenue & Growth
Revenue (TTM)	$874M	$0
Revenue Growth (YoY)	-7.4%	N/A
Forward Rev Growth	51.4%	231.1%
Profitability
Gross Margin (TTM)	98.2%	0.0%
Operating Margin (TTM)	0.0%	0.0%
EBITDA Margin (TTM)	-66.3%	0.0%
Net Margin (TTM)	-64.7%	0.0%
FCF Margin (TTM)	-64.2%	N/A
Net Income (TTM)	$-565M	$-179M
FCF (TTM)	$-561M	$-209M
EPS (TTM)	-$3.42	-$2.11
ROE (TTM)	-11092.0%	-2432.0%
ROA (TTM)	-1739.0%	-2223.0%
ROIC (TTM)	-2175.0%	-2432.0%
Financial Health
Cash	$350M	$162M
Debt	$1.91B	$0
Net Cash/Debt	$-1.56B	$162M
Current Ratio (TTM)	7.89x	18.53x
Quick Ratio (TTM)	7.73x	18.09x
Debt/Equity (TTM)	4.35x	0.00x
Debt/Assets (TTM)	0.0%	0.0%
Interest Coverage (TTM)	N/A	N/A
Net Debt/EBITDA (TTM)	0.00x	0.00x
Performance
Beta	0.38	3.19
52W Performance	-35.3%	384.7%
YTD Performance	-43.2%	180.2%
% from 52W High	-47.8%	-22.2%
% from 52W Low	6.2%	385.5%
Efficiency & Yields
Asset Turnover (TTM)	0.27x	0.01x
FCF Yield (TTM)	-7.5%	-2.8%
Earnings Yield (TTM)	-7.5%	-2.4%
Dividend Yield (TTM)	N/A	N/A
Other
Rule of 40	-71.6	0.0
EV/GP/RG	0.95	N/A
Ticker research	View IONS research	View SYRE research